Edaravone Improves Septic Cardiac Function by Inducing an HIF-1α/HO-1 Pathway

Figure 2

4-HNE staining of the myocardium and the cardiac level of oxidative stress markers in septic rats. Edaravone (EDA) at low (L), medium (M), or high (H) dose was injected intravenously 10 minutes before CLP, respectively. Lipid peroxidation level in the myocardium was visualized by (a) 4-HNE staining. Cardiac oxidative stress was indicated by levels of (b) MDA concentration, (c) catalase activity, (d) HO-1 activity, and (e) HIF-1α activity in the myocardium. versus Sham. versus CLP. Data are presented as mean ± SEM. per group.

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