Gossypol from Cottonseeds Ameliorates Glucose Uptake by Mimicking Insulin Signaling and Improves Glucose Homeostasis in Mice with Streptozotocin-Induced Diabetes

Figure 7

Analysis of glucose homeostasis in STZ-induced diabetic mice by gossypol (GSP). (a) STZ-induced diabetic mice were treated with GSP (1 mg/kg and 2.5 mg/kg) or rosiglitazone at 10 mg/kg, subjected to an oral glucose tolerance test and monitored after an oral load of glucose (1 mg/kg) at different time intervals. (b) Typical photomicrographs of the hematoxylin and eosin-stained pancreases of STZ-induced diabetic mice. (c, d) After the treatment, skeletal muscle tissues were excised and Western blotting analysis was performed. Statistical data are represented in the adjacent figure. Values are shown as means ± SEM in triplicate. versus no treatment (G1), versus STZ-control (G2). (e) Effect of GSP on gluconeogenesis enzymes. After the treatment, liver tissues were excised and Western blotting analysis for gluconeogenesis enzymes was performed.

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