Impaired Mitophagy of Nucleated Erythroid Cells Leads to Anemia in Patients with Myelodysplastic Syndromes

Figure 5

The correlation analysis between mitochondrial dysfunction in GlycoA⁺ NRBC and anemia associated with MDS. (a) In the high-risk MDS group, the amount of mitochondria in GlycoA⁺ NRBC was positively correlated with the count of ring sideroblasts in bone marrow samples (). (b) The level of LC3B in GlycoA⁺ NRBC was positively correlated with the hemoglobin level in high-risk MDS patients (). (c) The amount of mitochondria in GlycoA⁺ NRBC was negatively correlated with the hemoglobin level in high-risk MDS patients (). (d) The level of ROS in GlycoA⁺ NRBC was negatively correlated with ΔΨ_m in high-risk MDS patients ().

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