High Glucose-Induced ROS Production Stimulates Proliferation of Pancreatic Cancer via Inactivating the JNK Pathway

Figure 4

The JNK inhibitor SP600125 promotes the proliferation of high glucose-induced pancreatic cancer cells. (a) PANC-1 and CFPAC-1 cells cultured in LG and HG media for 24 h in the presence or absence of SP600125 (10 μM). Cells were subjected to immunoblot analyses for the expression of p-JNK, JNK, p-c-Jun, c-Jun, and GAPDH. (b) Western blotting analysis of Bax, Bcl-2, CDK2, cyclin D1, and p21 in PANC-1 and CFPAC-1 cells after treatment as described in (a). Data are presented as (). , , and , compared with the LG group.

(a)

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