Protocatechuic Acid Attenuates Trabecular Bone Loss in Ovariectomized Mice

Figure 5

Effects of PCA on serum levels of RANKL and OPG and RANKL/OPG ratio. OVX mice received vehicle, PCA (10 and 20 mg/kg b.w./day), or E₂ for 12 weeks. At the end of the experiment, sera were obtained; RANKL (a) and OPG (b) levels were determined using commercial ELISA kits; and the RANKL/OPG ratio was calculated (c). The results are expressed as mean ± SD (each group, ). between the sham and OVX-alone group. among OVX groups with or without interventions. among OVX groups with interventions. b.w.: body weight; E₂: 17β-estradiol; OPG: osteoprotegerin; OVX: ovariectomized; PCA: protocatechuic acid; RANKL: receptor activator of nuclear factor κB ligand.

(a)

(b)

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