Research Article
Palmitate Stimulates the Epithelial Sodium Channel by Elevating Intracellular Calcium, Reactive Oxygen Species, and Phosphoinositide 3-Kinase Activity
Figure 9
The proposed mechanism by which PA upregulates ENaC probably via a sequential pathway associated with elevation of intracellular Ca2+, ROS via an NADPH oxidase, and PIP3 via PI3K to elevate blood pressure.