Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways

Figure 1

Andrographolide (Andro) improved CCl₄-induced liver fibrosis in mice. (a) Representative histology of Sirius Red and immunohistochemical staining of α-SMA and TGF-β1. (b–d) Quantification of positive staining areas was measured by ImageJ software. (e) Hepatic hydroxyproline content. (f) The protein expression of α-SMA and TGF-β1 was examined by Western blot. (g, h) Serum levels of ALT and AST. . versus control mice. and versus mice induced by CCl₄.

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