Estradiol Alleviates Intervertebral Disc Degeneration through Modulating the Antioxidant Enzymes and Inhibiting Autophagy in the Model of Menopause Rats
Table 1
The level of E2 in serum and oxidative stress in IVD.
Sham
OVX + veh
OVX + E2
Serum E2 (pg/ml)
949.18 ± 104.4
216.51 ± 88.08
906.14 ± 104.2##
T-AOC (units/mg protein)
3.88 ± 0.95
1.69 ± 0.89
2.64 ± 0.92##
CAT (units/mg protein)
28.73 ± 11.67
29.28 ± 10.86
30.08 ± 11.73
SOD (units/mg protein)
45.90 ± 12.29
22.65 ± 8.73
44.24 ± 13.74##
GSH-Px (units/mg protein)
35.67 ± 13.31
14.15 ± 7.46
34.47 ± 11.92##
GSSG (units/mg protein)
3.12 ± 1.13
5.46 ± 1.33
3.56 ± 0.87#
GSH (units/mg protein)
7.71 ± 2.26
4.92 ± 1.4
8.12 ± 1.33#
Ratio of GSSG/GSH
0.50 ± 0.24
1.30 ± 0.75
0.46 ± 0.19##
Data are expressed as mean ± SD. , significant difference between OVX and sham. , significant difference between OVX and sham. ##, significant difference between OVX and OVX + E2. #, significant difference between OVX and OVX + E2.
