6-O-Galloylpaeoniflorin Attenuates Cerebral Ischemia Reperfusion-Induced Neuroinflammation and Oxidative Stress via PI3K/Akt/Nrf2 Activation

Figure 7

GPF diminished the inflammatory reaction through the PI3K/Akt pathway in a rat CIRI model in vivo. Iba1, phosphorylated p38 (p-p38), and phosphorylated JNK (p-JNK) were immunohistochemically stained in the rat brain slides of the indicated groups, respectively (a). The number of Iba1, p-p38, and p-JNK positively stained cells was counted (b). The gene expression levels of IL-1β and TNF-α in the indicated groups were detected by qPCR (c). Each group contains at least six rats. versus 0 mg/kg GPF in the CIRI models; versus 0 mg/kg GPF in the CIRI models; versus 10 mg/kg GPF in the CIRI models.

(a)

(b)

(c)