Resveratrol Improves Tube Formation in AGE-Induced Late Endothelial Progenitor Cells by Suppressing Syndecan-4 Shedding

Figure 7

Schematic diagram for the possible mechanisms of the protective effect of resveratrol in AGE-induced EPCs. In the diabetic condition, decreased sirt1 expression and increased ROS production triggers Synd4 shedding, which is responsible for impaired tube formation of EPCs. Treatment with resveratrol improves tube formation of EPCs via the regulation of the sirt1/ROS/Synd4/Akt/eNOS pathway.