Tryptophan Photoproduct FICZ Upregulates IL1A, IL1B, and IL6 Expression via Oxidative Stress in Keratinocytes

Figure 1

FICZ induces ROS production in a dose-dependent manner. HaCaT cells were treated with DMSO (0.1%, control) or FICZ (1, 10, 100, or 1000 nM) for 6 h, and ROS production was assessed by flow cytometry. Representative histograms of DCF fluorescence (a) are shown, along with the mean fluorescence intensities of DCF (b). Data are presented as means ± standard deviation ( per group). , , .

(a)

(b)