Tryptophan Photoproduct FICZ Upregulates IL1A, IL1B, and IL6 Expression via Oxidative Stress in Keratinocytes

Figure 6

FICZ induces IL6 expression in an AHR-dependent manner. HaCaT cells were transfected with negative control siRNA or AHR siRNA and further treated with DMSO (0.1%, control) or FICZ (100 nM) for 3 h. Expression of IL1A, IL1B, and IL6 was measured by qRT-PCR. FICZ-induced elevation of IL1A, IL1B, and IL6 mRNA expression was canceled in the AHR-knockdowned keratinocytes. Data are presented as means ± standard deviation ( per group). , , .