Tryptophan Photoproduct FICZ Upregulates IL1A, IL1B, and IL6 Expression via Oxidative Stress in Keratinocytes

Figure 7

NAC and AHR siRNA inhibit FICZ-induced IL6 production. (a) HaCaT cells were treated with DMSO (0.1%, control) or FICZ (100 nM) in the presence or absence of NAC (5 mM) for 6 or 12 h. (b) HaCaT cells were transfected with negative control siRNA or AHR siRNA and then further treated with DMSO (0.1%, control) or FICZ (100 nM) for 6 or 12 h. Production of IL6 in the culture supernatant was measured by ELISA. Data are presented as means ± standard deviation ( per group). , , .

(a)

(b)