Troxerutin Protects Kidney Tissue against BDE-47-Induced Inflammatory Damage through CXCR4-TXNIP/NLRP3 Signaling

Figure 1

Troxerutin reduces ACR, ROS, and inflammatory lesion in the kidney of BDE-47-treated mice. (a) ACR level (albumin-to-creatinine, mg/g; ) in BDE-47 mice including BDE-47 feeding and BDE-47/troxerutin were performed at 8 weeks. (b) ROS production was detected by fluorescent probe DCFH-DA. (c) Cytoplasm and nucleus NF-κB p65, iNOS, and COX-2 were examined by western blot. (d) shows the relative density analysis of cytoplasm and nucleus NF-κB p65, iNOS, and COX-2. The relative density is expressed as the ratio (iNOS/β-actin, COX-2/β-actin, cytoplasm NF-κB p65/β-actin, and nucleus NF-κB p65/H3). The control group is regarded as “1,” and all data are obtained at 8 weeks, which were the same as followed results of western blot. , , and versus the BDE-47 group ().

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