Troxerutin Protects Kidney Tissue against BDE-47-Induced Inflammatory Damage through CXCR4-TXNIP/NLRP3 Signaling

Figure 5

Troxerutin inhibited the interaction of CXCR4 and TXNIP in the kidney of BDE-47 mice. (a) TXNIP level was detected by western blot analysis after CXCR4 was immunoprecipitated with anti-CXCR4. and versus the BDE-47 group (). (b) CXCR4 level was measured by western blot analysis after TXNIP immunoprecipitation. and versus the BDE-47 group (). (c) CXCR4 siRNA decreased the expression of TXNIP in BDE-47-treated mice. and versus the adjacent groups. (). (d) TXNIP siRNA did not change the level of CXCR4 in BDE-47-treated mice. versus the BDE-47/Scr group (). CR4 si: CXCR4 siRNA; TXsi: TXNIP siRNA; Scr: scramble.

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