Long Noncoding RNAs in the Regulation of Oxidative Stress

Figure 1

Nrf2/Keap1/ARE pathway. Under the physiological condition, Nrf2 is degraded in a Keap1 manner, whereas with the stimulation of oxidative stress, Nrf2 detaches from Keap1, enters into the nucleus, and activates the transcription of a variety of antioxidation genes.