β-Lactoglobulin Heptapeptide Reduces Oxidative Stress in Intestinal Epithelial Cells and Angiotensin II-Induced Vasoconstriction on Mouse Mesenteric Arteries by Induction of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Translocation

Figure 3

(a) Vascular responses to increasing doses of angiotensin II (10^-9 to 10^-5) of mouse mesenteric arteries preincubated with increasing doses of BRP2 (1, 10, 50, and 100 μM). (b) Bar graph of the last time point of dose-response curve to angiotensin II (10^-5 M). (c) In situ detection of superoxide generation with DHE staining in segments of mesenteric arteries treated with Ang II (10^-5 M) alone or plus BRP2 (100 μM). Scale bar: 50 μm. (d) Graphs of superoxide production in mesenteric arteries measured continuously in the presence or absence of BRP2 by using 5 μmol L^-1 lucigenin-enhanced chemiluminescence. Values are , expressed as RLU/(s·mg dry weight) ().

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