Resveratrol Reverses Thioacetamide-Induced Renal Assault with respect to Oxidative Stress, Renal Function, DNA Damage, and Cytokine Release in Wistar Rats

Table 1

Effect of thioacetamide-induced changes alone and combined with resveratrol on the levels of kidney function and oxidative stress markers. Data are represented as of three independently performed experiments; each group had 8 rats for all experiments conducted: TAA-treated, 0.3% for two weeks; RSV-treated, 10 mg/kg bw for 2 weeks; and TAA+RSV-treated, 0.3%+10 mg/kg bw simultaneously for 2 weeks.

Parameters	Control	TAA-treated	RSV-treated	TAA+RSV-treated
BUN (mg/mg protein)	^b	^acd	^b	^b
Creatinine (mg/mg protein)	^bcd	^ac	^bd	^bc
Creatine kinase (U/mg protein)	^b	^ac	^b	^b
Lipid peroxidation (mmoles/mg protein)	^bc	^acd	^abd	^b
Catalase (U/mg protein)	^bd	^ad	^b	^b

^aSignificant () compared to control; ^bsignificant () compared to TAA-treated group; ^csignificant () compared to with the RSV-treated group; ^dsignificant () compared to simultaneous treatment of TAA+RSV-treated group.