Inhibition of HMGB1 Promotes Osseointegration under Hyperglycemic Condition through Improvement of BMSC Dysfunction

Figure 1

The design of in vivo study. (a) Time schedule of in vivo study. (b) Design graph of the screw-shaped titanium implant. (c) Implant in the tibia. (d, e) VOI of the peri-implant trabecular for μCT evaluation. VOI was defined as a hollow cylinder from 1.0 mm below the tibia cortex to 150 slices towards the bone marrow, extending with a radius of 350 μm from the implant body surface, which is 150 μm from the threads, between the green and purple circles in the graph.

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