[Retracted] The Healing of Oxidative Injuries with Trehalose in UVB-Irradiated Rabbit Corneas

Figure 7

Representative images and central corneal thickness of corneas treated with trehalose or buffer drops during repeated UVB irradiation and images of corneas treated with trehalose or buffer drops for fourteen days after the finished repeated UVB irradiation. (a) In the first group of corneas (corneas treated during irradiation), the best healing effects were obtained with the treatment with 6% trehalose, followed by the treatment with 3% trehalose. In (b), the central corneal thickness of these corneas is summarized. In trehalose-treated irradiated corneas, the values for days two and four are statistically different (, ) from the values of buffer-treated corneas. (c) In the second group, when corneas were at first irradiated (for 4 days) and then treated with buffer drops or trehalose drops (for 14 days), the best healing results were also obtained with 6% trehalose, followed by 3% trehalose. Corneal neovascularization was highly suppressed and corneal transparency restored. In contrast, after the treatment of UVB-irradiated corneas with buffer drops, corneas healed with untransparent scar tissue and corneal neovascularization appeared (arrow). Comparison with the control eye. (d) The central corneal thickness of corneas irradiated (for 4 days) and then treated with buffer drops or trehalose drops (for 14 days). The central corneal thickness after trehalose treatment on days ten and fourteen was statistically different () from the values of buffer-treated corneas. After the treatment with 6% trehalose, the values of the central corneal thickness on day fourteen reached the values before injury.

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