miR-181c-5p Exacerbates Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis via Targeting PTPN4

Figure 2

Transfection of cells with miR-181c-5p agomir (miR-181c-5p) resulted in significant overexpression of miR-181c-5p in H9C2 cardiomyocytes (a), and overexpression of miR-181c-5p exacerbated the H/R-induced H9C2 cell injury, as evidenced by further increased LDH release (b), reduced cell viability (c), and increased apoptotic cell death as evidenced by increased cleaved caspase 3 and Bax/Bcl-2 (d) and increased TUNEL-positive cells (e). Scale bar: 200 μm. Data are shown as ; vs. CTL, vs. NC agomir (NC), .

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