Research Article

5α,6α-Epoxyphytosterols and 5α,6α-Epoxycholesterol Increase Oxidative Stress in Rats on Low-Cholesterol Diet

Table 1

Oxidative stress markers ( (SD)) (MDA: malondialdehyde levels, anti-7-ketoCH- anti-ketocholesterol antibody levels; FRAP: total antioxidant capacity of plasma levels; CAT: activity of catalase; GPx: activity of glutathione peroxidase; GR: activity of glutathione reductase; SOD: activity of superoxide dismutase; GST: activity of glutathione S-transferase; PON-1: activity of paraoxonase-1) in plasma (p), serum (s), and erythrocytes (e) of rats fed with 5α,6α-epoxycholesterol (ECh group) and 5α,6α-epoxyphyosterols (ES group) vs controls (C).

ECh groupES groupC group

MDA (p) [μmol/L]0.0545
Conjugated dienes (p) [μmol/L]<0.01
Anti-7-ketoCh (s) [AU/mL]<0.01
FRAP (p) [μmol/L]<0.01
CAT(e) [kIU/g Hb]0.600
GPx (e) [IU/g Hb]<0.01
GR (e) [IU/g Hb]<0.001
SOD (e) [NU/g Hb]<0.001
GST (e) [IU/g Hb]0.509
PON-1 (s) [IU/L]<0.001