TNFα-Mediated Necroptosis Aggravates Ischemia-Reperfusion Injury in the Fatty Liver by Regulating the Inflammatory Response

Figure 8

TNFα-mediated necroptosis aggravates IRI in the fatty liver by regulating the inflammatory response. Macrophages were activated during IRI, which secreted more TNFα in the fatty liver compared with the normal liver. Necroptosis induced by TNFα was activated in NAFLD, leading to more severe IRI. Necroptosis promoted the production of DAMPs, which increased signaling pathways of inflammation and the soakage of inflammation cells to aggravate IRI. Inhibition of necroptosis with Nec-1 and GSK872 could decrease the signaling pathway of inflammation and ROS production to protect the liver from IRI.