Mitochondria-Targeted Peptide SS31 Attenuates Renal Tubulointerstitial Injury via Inhibiting Mitochondrial Fission in Diabetic Mice

<div>Renal IL-1<i>β</i>, Caspase1, Mfn1, and Drp1 expression in diabetic mice following SS31 treatment. (a) Renal immunohistochemical staining with anti-IL-1<i>β</i> antibody (upper panel), anti-Caspase1 antibody (middle panel), anti-Drp1 antibody (middle panel), and anti-Mfn1 (lower panel) (magnification ×400). (b) Western blot analysis of Mfn1 (upper panel), Drp1 (middle panel), Caspase1 (middle panel), and IL-1<i>β</i> (bottom panel) protein expression. (c–f) Densitometric analyses of the Western blotting results: IL-1<i>β</i> to <i>β</i>-actin (c), Caspase1 to <i>β</i>-actin (d), Drp1 to <i>β</i>-actin (e), and Mfn1 to <i>β</i>-actin (f). 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Mitochondria-Targeted Peptide SS31 Attenuates Renal Tubulointerstitial Injury via Inhibiting Mitochondrial Fission in Diabetic Mice 