Cyclophilin A Protects Cardiomyocytes against Hypoxia/Reoxygenation-Induced Apoptosis via the AKT/Nox2 Pathway

Figure 4

CyPA decreased O₂⁻ production under hypoxia/reoxygenation conditions. The roles of CyPA (1000 ng/L) on O₂⁻ production in H9c2 cells incubated under H/R conditions and the changes in the roles of CyPA (1000 ng/mL) on O₂⁻ production after GSK690693 (10 μM) intervention are revealed in representative fluorescent images for DHE staining (a) and summarized data (b). Photographs were taken at ×100 magnification. The O₂⁻ production dependent on NADPH oxidase in the H9c2 cells is revealed in representative ESR CM nitroxide spectra resulting from CMH reacted with O₂⁻ (c) and summarized data (d). vs. the H/R+CyPA group ().

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