Modulation of Antioxidant Potential with Coenzyme Q10 Suppressed Invasion of Temozolomide-Resistant Rat Glioma In Vitro and In Vivo

Figure 2

Cell death induction in a microfluidic device. (a) Representative images of microfluidic devices with RC6 cells embedded in collagen hydrogel in the central microchamber. Growth medium and medium supplemented with 10 μM CoQ10, 250 μM TMZ, or their combination were perfused through both lateral microchannels, and after 72 h, cell viability was assessed by CAM (green) and PI (red) staining. The position of the pillars is defined with white dashed lines. Scale ; (b) the graph displays the PI fluorescence intensity along the delimited region in control, single, and combined CoQ10 and TMZ treatments.

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