FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX

<div>Histological changes of male transgenic (Tg) and non-Tg mouse kidneys at week 12. (a) Hematoxylin and eosin staining, (b) periodic-acid Schiff staining, and (c) Masson’s trichrome staining of normal, diabetic, and diabetic transgenic (Tg) mouse kidneys at week 12. Scale bars, 50 <i>μ</i>m. (d) Relative basement membrane thickness in PAS staining. (e) Relative collagen fibers in Masson staining. (f) Nucleus (N), mitochondria (M) of RPTCs, and interstitial collagen fibers (F) as viewed by transmission electron microscopy. Original magnification, 4000x. (g) Representative pictures of TUNEL staining. Scale bars, 100 <i>μ</i>m. (h) Quantitative analysis of the number of apoptotic cells per field. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX 

Figure 3 | FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX 