Research Article
Genipin Ameliorates Carbon Tetrachloride-Induced Liver Injury in Mice via the Concomitant Inhibition of Inflammation and Induction of Autophagy
Figure 2
Effect of genipin and 3-MA on LC3-II, p62, ATG5, ATG7, ATG12, and Beclin-1 protein expressions (a) and transmission electron microscopy images (b) at 48 h after CCl4 exposure. Mice were intraperitoneally injected a mixture of CCl4 (50%) and oil (50%) at a dose of 2 ml·kg-1 body weight. Mice received an intravenous injection of 2.5 mg·kg-1 genipin 2 h before CCl4 exposure. Mice were pretreated with 3-MA before genipin. Results are presented as for each group. Significantly different (, , and ) from the control group. Significantly different (# and ##) from the CCl4 group. Significantly different (&, &&, and &&&) from the CCl4+genipin group.
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