Genipin Ameliorates Carbon Tetrachloride-Induced Liver Injury in Mice via the Concomitant Inhibition of Inflammation and Induction of Autophagy

Figure 5

Effect of genipin and SB203580 on serum ALT/AST activity (a), H&E staining (b), macroscopic examination (c), and LC3-II and p62 protein expressions (d). Mice were intraperitoneally injected a mixture of CCl₄ (50%) and oil (50%) at a dose of 2 ml·kg^-1 body weight. Mice received an intravenous injection of 2.5 mg·kg^-1 genipin 2 h before CCl₄ exposure. Mice were pretreated with SB203580 before genipin. Significantly different () from the control group. Significantly different (^#, ^##, and ^###) from the CCl₄ group. Significantly different (^&& and ^&&&) from the CCl₄+genipin group.

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