Nrg1 Intracellular Signaling Is Neuroprotective upon Stroke

Figure 8

Nrg1-ICD is neuroprotective upon stroke in vivo. (a–d) Representative images of infarcted areas in the motor cortex of mice infected to express GFP as control (a, b) of Nrg1-ICD (c, d) at low (a, c) and high (b, d) magnification. GFP labeling (c, d) and counterstaining in DAPI (a, d). The dotted lines indicate the core of the infarcted regions. Arrowheads indicate surviving neurons expressing Nrg1-ICD inside the infarct (d). The boxed regions in (a) and (c) depict the areas magnified in (b) and (d), respectively. Scale bar in (a, c), 500 μm. MOp: primary motor cortex; MOs: secondary motor cortex. Scale bar in (b, d), 100 μm.