Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1R/TGF-β1/Smad2/3 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats

Figure 2

Atrial structural remodeling measured by Masson’s staining and TEM in WKY 4m-o, WKY 24m-o, SHR 4m-o, and SHR 24m-o rats. (a) In Masson’s staining, the collagen was stained blue, and cardiomyocytes were stained red. In the top panel, magnification is ×400; in the bottom panel, magnification is ×8000, magnifying the blue grid from the top panel. (b) TEM photos: in the top panel, magnification is ×12000; in the bottom panel, magnification is ×240000, magnifying the blue grid from the top panel.

(a)

(b)