Prevention of Huntington’s Disease-Like Behavioral Deficits in R6/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress

Figure 2

Effect of tolfenamic acid on motor deficits in R6/1 mice. R6/1 mice exhibited progressive weakening in muscle strength in the grip strength test (a) and a decrease in fall latency time (b) in the rotarod test compared with control mice. Tolfenamic acid treatment improved performance in the rotarod test, but not in the grip strength test. All results are expressed as . ; and versus control; and versus model.

(a)

(b)