Prevention of Huntington’s Disease-Like Behavioral Deficits in R6/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress

<div>Effect of tolfenamic acid treatment on the expression of mutant huntingtin (Htt) and Sp1 in the striatum. Both doses of tolfenamic acid (25 or 50 mg/kg) significantly decreased the expression of mHtt and Sp1 (a) and decreased the intensity and positive area of the EM48-positive cell (b) in the striatum. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Prevention of Huntington’s Disease-Like Behavioral Deficits in R6/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress 

Figure 5 | Prevention of Huntington’s Disease-Like Behavioral Deficits in R6/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress 