Research Article

Prevention of Huntington’s Disease-Like Behavioral Deficits in R6/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress

Figure 6

Effect of tolfenamic acid on the autophagy pathway in the striatum. Both doses of tolfenamic acid significantly increased the LC3-II/LC3-I ratio and decreased the expression of P62. All results are expressed as the . ; versus control; versus model.