Melatonin Alleviates Radiation-Induced Lung Injury via Regulation of miR-30e/NLRP3 Axis

Figure 6

A schematic model illustrating the underlying mechanism of the alleviated effect of melatonin on radiation-induced lung injury through the miR-30e/NLRP3 signaling pathway. TLRs and DAMPs activated by radiation further promoted the ROS generation and, secondly, the transcription of NLRP3. Moreover, miR-30e was downregulated in the macrophages of an irradiated cell model but its target gene NLRP3 was upregulated, thus leading to the enhanced assembly of the NLRP3 inflammasome, then the cleavage of pro-caspase-1 and pro-IL-1β. Green lines: facilitation. Red lines: inhibition.