Green Tea Prevents NAFLD by Modulation of miR-34a and miR-194 Expression in a High-Fat Diet Mouse Model

Figure 1

Green tea prevents obesity attenuating inflammation in HFD-fed mice with NAFLD. (a) Body weight, (b) body weight gain, (c) subcutaneous fatty depots, (d) epididymal, (e) brown adipose tissue, (f) adiposity index, (g) plasma levels of cytokines and adiponectin, (h) fasting glycemia, (i) calculation of the glucose decay constant in the bloodstream (kITT), (j) plasma insulin concentration, (k) HOMA index, (l) hepatic gene expression of Ir, Irs2, and Pi3k, (m) and hepatic glycogen content. The ITT assessment was performed at 0, 5, 15, 30, 60, and 90 minutes after intraperitoneal administration of insulin. Results are presented as of at least 06 animals per group. ANOVA one- and two-way and Student’s -test were used for all the statistical analysis. When the difference was statistically significant, the following overwritten letters were used: ^aCompared to the Cont group. ^bCompared to the HFD group.

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