Psoralea corylifolia L. Seed Extract Attenuates Methylglyoxal-Induced Insulin Resistance by Inhibition of Advanced Glycation End Product Formation

Figure 1

PCS extract improves glucose tolerance and insulin sensitivity in MGO-administered mice. Oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) were performed at week 18 of the experiment. Blood glucose levels (a) and area under the curve (AUC) (b) of OGTT. Blood glucose levels (c) and AUC (d) of ITT. Data are shown as (/group); in AUC (b, d). ^% CON vs. MGO. ^%% CON vs. MGO. ^& MGO vs. MGO+PCS 200.^$, ^$$ MGO vs. MGO+PCS 500. ^# MGO vs. MGO+AG. CON: control; MGO: methylglyoxal; MGO+PCS 200: methylglyoxal+PCS extract 200 mg/kg; MGO+PCS 500: methylglyoxal+PCS extract 500 mg/kg; MGO+AG: methylglyoxal+aminoguanidine.

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