Ghrelin Aggravates Prostate Enlargement in Rats with Testosterone-Induced Benign Prostatic Hyperplasia, Stromal Cell Proliferation, and Smooth Muscle Contraction in Human Prostate Tissues

Figure 6

Effects of GHSR agonists on contractility of human prostate tissues. (a) Effects of L-692,585 (300 nM) on contractions of human prostate strips induced by electric field stimulation (tissues from patients). (b) Effects of L-692,585 (300 nM) on contractions of human prostate strips induced by noradrenaline (tissues from patients). (c) Effects of MK0677 (100 nM) on contractions of human prostate strips induced by the α₁-adrenoceptor agonist phenylephrine (tissues from patients). In all series, tissue from each patient being allocated to control and GHSR agonist group in each experiment. Data are in frequency- and concentration-response curves ( value from 2-way ANOVA for comparison between groups as indicated in frequency and concentration response curves) (A), values for each single experiment (calculated by curve fitting) in (b) and (c) (B), and from 5 of 6 experiments in (a, B) (as feasible calculation was not possible for one experiment) (^# vs. control after Wilcoxon Rank Sum test), single values for 32 hertz-induced contractions in (a, C), and pEC₅₀ values for each single experiment (calculated by curve fitting) in (b) and (c) (C).

(a)

(b)

(c)