Nicorandil Attenuates LPS-Induced Acute Lung Injury by Pulmonary Endothelial Cell Protection via NF-κB and MAPK Pathways

Figure 1

C57B/L mice were treated with Nico (12.5, 25, and 50 mg/kg) for 3 consecutive days by gavage. On day 3, Nico was given at 1 hr before intratracheal instillation of LPS or saline administration. Mice were sacrificed at 24 hr after LPS administration. Nico: nicorandil.