Dose-Dependent Behavioral and Antioxidant Effects of Quercetin and Methanolic and Acetonic Extracts from Heterotheca inuloides on Several Rat Tissues following Kainic Acid-Induced Status Epilepticus

Figure 2

Effects of quercetin on the activity of the antioxidant enzymes GPx, GR, CAT, and SOD in the cerebellum (A), prefrontal cortex (B), cerebral hemispheres (C), and medulla (D) of Wistar rats during KA-induced injury. The results were analyzed by one-way analysis of variance (ANOVA), and Bonferroni’s multiple comparisons test was used to compare the outcomes between the experimental and respective control groups (KA only, black bar). For GPx and SOD: ^xxx in the extracts and quercetin and in all its doses and in all tissues vs. the KA group; for GR: ^xxx in the extracts and quercetin and in all its doses and in all brain tissues except in the Q30+KA group in the cerebral hemispheres and medulla vs. KA, ^xx in the Q30+KA group in the cerebral hemispheres and medulla vs. KA; for CAT: ^xxx in the extracts and quercetin and in all its doses and in all brain tissues except in the Q30+KA group in the medulla vs. KA, ^xx in the Q30+KA group in the medulla vs. KA. Each determination was performed in triplicate, and the data are expressed as the ( per group). ns: not significant.