DNA Methylation of miR-122 Aggravates Oxidative Stress in Colitis Targeting SELENBP1 Partially by p65NF-κB Signaling

Figure 2

High expression of SBP1 in the established TNBS-induced colitis model. (a–c) TNBS or ethanol (control group) administration caused variation about body weight, DAI, and histology score in the murine model. (d, e) Western blotting analysis and immunohistochemical staining were performed to study the SBP1 level in TNBS-induced colitis compared with ethanol-treated mice. SGK1-dependent staining is indicated by brown areas. (f) Colocalization of SBP1 and E-cadherin by the immunofluorescence assay indicated the localization of SBP1.

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