Dibromoacetic Acid Induced Hepatotoxicity in Mice through Oxidative Stress and Toll-Like Receptor 4 Signaling Pathway Activation

<div>Effects of DBA on Toll-like receptor 4 (TLR4) and its adaptor molecules. Oral administration of DBA results in activation of TLR4-mediated MyD88-dependent pathway in the liver of Balb/c mice. (a) Representative blots for I<i>κ</i>B-<i>α</i>, MyD88, NF-<i>κ</i>B p65, TLR4, and TRAF-6 with the respective blot for <i>β</i>-actin used for normalization in the upper panel and the folder change of target protein/<i>β</i>-actin in each group in the bottom panel. (b) Representative blots for p38, phosphorylated p38, JNK, and phosphorylated JNK with the respective blot for <i>β</i>-actin used for normalization in the upper panel and the folder change of target protein/<i>β</i>-actin in each group in the bottom panel. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Dibromoacetic Acid Induced Hepatotoxicity in Mice through Oxidative Stress and Toll-Like Receptor 4 Signaling Pathway Activation 