Metformin Ameliorates Testicular Damage in Male Mice with Streptozotocin-Induced Type 1 Diabetes through the PK2/PKR Pathway

Figure 1

Histomorphological damage in diabetic mice. (a–h) HE staining of testes sections at 2 months, 3 months, 4 months, and 5 months. The white arrowhead shows a normal spermatogenic epithelium, the white triangle shows spermatogenesis, the black arrowhead shows fewer spermatogenic cell layers in the DM group than in the control group, and the black triangle shows sparse spermatogenesis in the DM group. Magnification = 400x; scale bar = 20 μm; .