Metformin Ameliorates Testicular Damage in Male Mice with Streptozotocin-Induced Type 1 Diabetes through the PK2/PKR Pathway

Figure 4

Histomorphological damage in diabetic mice. (a, b) Met prevented biotin from entering the seminiferous tubules. The white arrow indicates biotin between the tubules, and the white triangle indicates biotin in the seminiferous tubules. (a) ; (b) ; ; . (c) Met reversed the morphology of testicular tissue in mice, as determined by HE staining. The black arrowhead shows the spermatogenic cell layers, and the black triangle shows spermatogenesis. ; ; . (d) Met restored the organelle damage in testicular cells, and the red arrow indicates vacuolar degeneration or disintegration in the cytoplasm.