Internalization and Transportation of Endothelial Cell Surface K<sub>Ca</sub>2.3 and K<sub>Ca</sub>3.1 in Normal Pregnancy and Preeclampsia

<div>Role of clathrin in the K<sup>+</sup> channel degradation. (a) Clathrin levels in ECs treated with NNP or NP serum. Alteration in clathrin levels was not found between ECs treated with NNP or NP serum. (b) Clathrin levels in ECs treated with NP or PE serum. (c) Membrane clathrin levels in ECs treated with NP or PE serum. (d) Colocalization of clathrin and K<sub>Ca</sub>3.1 was enhanced by PE serum or LPC. (e, f) Treatment with the clathrin inhibitor CPZ (2 <i>μ</i>M) recovered K<sub>Ca</sub>2.3 (e) or K<sub>Ca</sub>3.1 (f) levels in the ECs treated with PE serum or LPC. Blots shown are representative of three to six experiments performed with three to six different cultures. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Internalization and Transportation of Endothelial Cell Surface K<sub>Ca</sub>2.3 and K<sub>Ca</sub>3.1 in Normal Pregnancy and Preeclampsia 

Oxidative Medicine and Cellular Longevity

Internalization and Transportation of Endothelial Cell Surface KCa2.3 and KCa3.1 in Normal Pregnancy and Preeclampsia

Figure 3

Internalization and Transportation of Endothelial Cell Surface K_Ca2.3 and K_Ca3.1 in Normal Pregnancy and Preeclampsia