Research Article
Internalization and Transportation of Endothelial Cell Surface KCa2.3 and KCa3.1 in Normal Pregnancy and Preeclampsia
Figure 7
A schematic model for altered redox state-induced modulation of PM-localized KCa2.3 and KCa3.1 in NP and PE. (a) PM-localized KCa2.3 and KCa3.1 are internalized via caveola- or clathrin-dependent processes and transported via a Rab5c- and EEA1-dependent process to early endosome. (b) Compared to NNP, the internalization and transport processes are delayed by H2O2 in NP, thus elevating PM-localized KCa2.3 and KCa3.1 levels. However, compared to NP, the internalization and transport processes are facilitated in PE, thus reducing PM-localized KCa2.3 and KCa3.1 levels.
| (a) |
| (b) |