Research Article

Simvastatin Mitigates Apoptosis and Transforming Growth Factor-Beta Upregulation in Stretch-Induced Endothelial Cells

Figure 3

Simvastatin protected ECs from apoptosis induced by stretch. (a) Bax mRNA of ECs under 20% stretch with different concentrations of simvastatin was measured by qRT-PCR analysis. (b) Antiapoptotic and proapoptotic proteins of ECs under 20% stretch with simvastatin or not were detected by Western blot. (c) Reduced mitochondrial membrane potential of ECs under 20% stretch was reversed by simvastatin. (d–f) NOX2 upregulation induced by stretch was inhibited by simvastatin, and even NOX4 expression was reduced. , .
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