Simvastatin Mitigates Apoptosis and Transforming Growth Factor-Beta Upregulation in Stretch-Induced Endothelial Cells

Figure 6

ROS involved in stretch-induced TGF-β increase, which was suppressed by simvastatin. (a, b) Stretch-treated ECs were pretreated with N-acetyl-cysteine (NAC) or simvastatin; the phosphorylation of P38MAPK, JNK, and NF-κB and TGF-β expressions was significantly suppressed. (c) A graph showed that simvastatin alleviated the apoptosis of ECs and upregulation of TGF-β induced by stretch through inhibiting ROS production.

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