Early Oxidative Stress Response in Patients with Severe Aortic Stenosis Undergoing Transcatheter and Surgical Aortic Valve Replacement: A Transatlantic Study

Table 4

Changes in oxidative stress-related biomarkers according to transcatheter or surgical aortic valve replacement.

Measured parameter	TAVR ()	SAVR ()	Adjusted value
GSH S1			0.018
GSH S2			0.931
GSH S3 (nmol/mg protein)			0.498
Slope for trend	0.022	-0.330
value	0.698	<0.001
GSSG S1			0.942
GSSG S2			0.650
GSSG S3 (nmol/mg protein)			0.475
Slope for trend	-0.005	0.003
value	0.842	0.804
GSH/GSSG S1			0.568
GSH/GSSG S2			0.380
GSH/GSSG S3			0.237
Slope for trend	1.860	-0.880
value	0.319	0.199
FRAP S1			0.410
FRAP S2			0.017
FRAP S3 (μmol/L)			0.212
Slope for trend	12.6	-0.22
value	0.027	0.983
8-Isop S1			0.553
8-Isop S2			0.635
8-Isop S3 (pg/mL)			0.046
Slope for trend	-2.56	46.5
value	0.86	0.028

GSH = reduced glutathione; GSSG = oxidized glutathione; FRAP = ferric-reducing ability of plasma; S = sample; SAVR = surgical aortic valve replacement; SD = standard deviation; TAVR = transcatheter aortic valve replacement; 8-Isop = 8-isoprostane.