|
| Classes | Name and/or chemical structure of isolated or synthesized compound | Activity (IC50)/Leishmania specie (evolutive form) | SI | Ref. |
|
| Monoterpene hydrocarbon | 3-Carene (119) | 72.5 μg.mL−1/L. amazonensis (promastigote) | nd | [187] |
| p-Cymene (11) | >1000 μg.mL−1/L. amazonensis (promastigote) | nd | [187] |
| α-Pinene (118) | 19.7 μg.mL−1/L. amazonensis (promastigote)
16.1 μg.mL−1/L. amazonensis (axenic amastigote)
15.6 μg.mL−1/L. amazonensis (intracellular amastigote) | 21.5 for promastigote, 26.4 for axenic amastigote, and 27.2 for intracellular amastigote | [169] |
|
| Oxygenated monoterpene | Carvacrol (10) | 25.4 μg.mL−1/L. amazonensis (promastigote) | nd | [187] |
| Thymol (1) | 26.8 μg.mL−1/L. amazonensis (promastigote)
9.8 μg.mL−1/L. chagasi (promastigote) | nd | [187, 200] |
| (−)-Carvone (13) | 194.7 μg.mL−1/L. amazonensis (promastigote) | nd | [187] |
| (−)-Menthol (130) | 198.9 μg.mL−1/L. amazonensis (promastigote) | nd | [187] |
| 1,8-Cineole (124) | 568.1 μg.mL−1/L. amazonensis (promastigote) | nd | [187] |
| Linalool (3) | 550 μg.mL−1/L. infantum chagasi (axenic amastigote)
276.2 μg.mL−1 or 8.3 ng.mL−1/L. amazonensis (promastigote)
15.5 ng.mL−1/L. amazonensis (amastigote) | nd | [162] [187] [166] |
| Citral (63) | 8.0 μg.mL−1/L. amazonensis (promastigotes)
25.0 μg.mL−1/L. amazonensis (amastigotes) | 6.3 for promastigote and 2.0 for amastigote | [167] |
| Geraniol (9) | 3.78 μg.mL−1/L. infantum (promastigote)
5.57 μg.mL−1/L. major (promastigote) | 21.26 for L. infantum
14.43 for L. major | [174] |
| Camphor (14) | 5.55 μg.mL−1/L. infantum (promastigote)
7.90 μg.mL−1/L. major (promastigote) | 4.56 for L. infantum
3.20 for L. major | [174] |
| Carvacrol (10) | 7.35 μg.mL−1/L. infantum (promastigote)
9.15 μg.mL−1/L. major (promastigotes)
2.3 μg.mL−1/L. chagasi (promastigote) | 34.08 for L. infantum and
27.37 for L. major | [174, 200] |
| Ascaridole (37) | 0.1 μg.mL−1/L. amazonensis (promastigote)
0.3 μg.mL−1/L. amazonensis (amastigote) | 4.0 | [64] |
|
| Oxygenated sesquiterpene | (−)-α-Bisabolol (165) | 10.99 μg.mL−1/L. infantum (promastigote)
4.95 μg.mL−1/L. amazonensis (promastigote) | 9.38 for L. amazonensis | [183, 185] |
| Caryophyllene Oxide (38) | 4.9 μg.mL−1/L. amazonensis (promastigote)
13.6 μg.mL−1/L. amazonensis (amastigote) | 1.0 | [64] |
| β-Caryophyllene (22) | 1.3 μg.mL−1/L. amazonensis (amastigote)
1.06 μg.mL−1/L. infantum (promastigote)
1.33 μg.mL−1/L. major (promastigote) | 48.9 for L. amazonensis, 20.82 for L. infantum, and 16.59 for L. major | [174] |
|
| Phenolic compounds | Eugenol (2) | 220 μg.mL−1/L. infantum (promastigote)
500 μg.mL−1/L. infantum chagasi (axenic amastigote)
82.9 μg.mL−1/L. amazonensis (promastigote) | nd | [166, 187] |
|
| Phenylpropanoid | Isoborneol (179)
| 190.2 μg.mL−1/L. amazonensis (promastigote) | nd | [187] |
|
| Diterpene | 6,7-Dehydroroyleanone (167) | μg.mL−1/L. amazonensis (promastigote) | 0.22 | [192] |
|
| Others | | 8.75 μg.mL−1/L. amazonensis (promastigotes) | >45.71 | [186] |
| 10.49 μg.mL−1/L. amazonensis (promastigotes) | >38.13 | [186] |
| 4.71 μg.mL−1/L. amazonensis (promastigotes) | >84.92 | [186] |
| 11.40 μg.mL−1/L. amazonensis (promastigotes) | nd | [186] |
| 10.56 μg.mL−1/L. amazonensis (promastigotes) | nd | [186] |
| 5.91 μg.mL−1/L. amazonensis (promastigotes) | nd | [186] |
| 18.08 μg.mL−1/L. amazonensis (promastigotes) | nd | [186] |
| 22.30 μg.mL−1/L. amazonensis (promastigotes) | nd | [186] |
| 13.60 μg.mL−1/L. amazonensis (promastigotes) | nd | [186] |
5-[(3E)-Oct-3-en-1-il]-1,3-benzodioxole | 82.5 μg.mL−1/L. infantum (promastigotes) | 2.4 | [186] |
|
